Zynlonta Dosage Details: Formulation, Potency, Administration Methods, and Additional Information
New Treatment Option for Large B-Cell Lymphoma: Zynlonta
Zynlonta, a brand-name prescription medication, has been approved for treating certain types of large B-cell lymphoma in adults. This biologic drug is given as an IV infusion and is used to treat diffuse large B-cell lymphoma (DLBCL), DLBCL that begins as low grade lymphoma, and high grade B-cell lymphoma.
The drug is typically given in cycles that last 3 weeks, with the drug administered on the first day of each cycle. The infusion takes about 30 minutes to complete. It is important to note that Zynlonta is a long-term treatment, and if it is safe and effective for you, you'll likely receive it long term.
Zynlonta comes as a powder in a single-dose vial, mixed with a liquid to create a solution for IV infusion. It is given in a doctor's office, clinic, or infusion center by a healthcare professional.
Dexamethasone, a steroid, is often prescribed to help reduce the risk of side effects related to the Zynlonta infusion. Your doctor may prescribe dexamethasone for 3 days in each cycle, to be started a day before your Zynlonta dose.
The dosage of Zynlonta can vary depending on the individual's cancer treatment schedule and other factors. For B-cell lymphoma treatment, the dosage amount may be 0.15 mg per kilogram (mg/kg) for the first two cycles, and 0.075 mg/kg for subsequent cycles. Your doctor may need to calculate and adjust your Zynlonta dosage at every visit, depending on your weight.
Zynlonta treatment carries risks including cytokine release syndrome, an important safety consideration. Common side effects associated with Zynlonta include cardiovascular effects such as hypotension, tachycardia, edema, and hypertension; central nervous system effects like headache, encephalopathy, fatigue, delirium, pain, chills, anxiety, and dizziness; dermatologic effects such as skin rash; and endocrine and metabolic effects including hypokalemia, hypophosphatemia, hyponatremia, and weight loss.
It is crucial to discuss any potential side effects with your healthcare provider and to follow all safety procedures when handling, administering, and disposing of Zynlonta, as home infusions are not an option with this drug.
[1] Zynlonta Product Labeling [2] [3] [4] Various Lymphoma Drug References (Not specific to Zynlonta)
- Zynlonta, a new treatment option for large B-cell lymphoma, is now approved for adults with specific types of lymphoma, such as DLBCL and high grade B-cell lymphoma.
- As part of the treatment schedule, Dexamethasone, a steroid, may be prescribed to help reduce side effects related to Zynlonta infusion.
- Zynlonta requires medical supervision in a doctor's office, clinic, or infusion center, as it is administered as an IV infusion by a healthcare professional.
- The science behind Zynlonta and other cancer treatments falls under the field of oncology, making it a crucial area of study and research in the field of health and wellness.
- It's essential to be aware of potential side effects such as cytokine release syndrome, cardiovascular effects, central nervous system effects, dermatologic effects, and endocrine and metabolic effects associated with Zynlonta treatment.
